(2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Base Information

• Chemical Name: (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester
• CAS No.: 349150-78-3
• Molecular Formula: C₁₂H₁₃F₃N₂O₄
• Molecular Weight: 306.241
• Mol file: 349150-78-3.mol

Synonyms:(2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Chemical Property of (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

There total 3 articles about (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

glycine ethyl ester hydrochloride (623-33-6) + 2-(trifluoromethyl)-6-nitrobenzyl bromide (133605-26-2) → (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (349150-78-3)

Guidance literature:

glycine ethyl ester hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

2-(trifluoromethyl)-6-nitrobenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Further stages.;

DOI:10.1021/jm000352g

Reference yield:

2-methyl-1-nitro-3-(trifluoromethyl)benzene (6656-49-1) + glycine ethyl ester hydrochloride (623-33-6) → (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (349150-78-3)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; sodium hydrogencarbonate; In ethanol; ethyl acetate; benzene;

Reference yield:

2-methyl-1-nitro-3-(trifluoromethyl)benzene (6656-49-1) → (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (349150-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 16 h / Irradiation; heating

2.1: NaH / dimethylformamide / 0.5 h

2.2: 60 percent / dimethylformamide / 5 h / 20 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000352g

upstream raw materials:

glycine ethyl ester hydrochloride

2-(trifluoromethyl)-6-nitrobenzyl bromide

2-methyl-1-nitro-3-(trifluoromethyl)benzene

Downstream raw materials:

(2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester