(2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Base Information

• Chemical Name: (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester
• CAS No.: 58579-47-8
• Molecular Formula: C₁₂H₁₅F₃N₂O₂
• Molecular Weight: 276.259
• Mol file: 58579-47-8.mol

Synonyms:(2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Chemical Property of (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

There total 3 articles about (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (349150-78-3) → (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (58579-47-8)

Guidance literature:

With hydrogen; 10percent Pd/C; In tetrahydrofuran; under 750.075 Torr;

DOI:10.1021/jm000352g

Reference yield:

2-methyl-1-nitro-3-(trifluoromethyl)benzene (6656-49-1) → (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (58579-47-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 72 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 16 h / Irradiation; heating

2.1: NaH / dimethylformamide / 0.5 h

2.2: 60 percent / dimethylformamide / 5 h / 20 °C

3.1: 83 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 750.08 Torr

With N-Bromosuccinimide; hydrogen; sodium hydride; dibenzoyl peroxide; 10percent Pd/C; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000352g

Reference yield:

2-(trifluoromethyl)-6-nitrobenzyl bromide (133605-26-2) → (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester (58579-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 60 percent / dimethylformamide / 5 h / 20 °C

2.1: 83 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 750.08 Torr

With hydrogen; sodium hydride; 10percent Pd/C; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm000352g

upstream raw materials:

(2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester

2-methyl-1-nitro-3-(trifluoromethyl)benzene

2-(trifluoromethyl)-6-nitrobenzyl bromide