3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Base Information

Chemical Name:3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone
CAS No.:184969-61-7
Molecular Formula:C₂₈H₃₉Cl₂NO₃Si
Molecular Weight:536.614
Hs Code.:

Synonyms:3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

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Chemical Property of 3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Chemical Property:

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Technology Process of 3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

There total 8 articles about 3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: CH₃ OH(NH₃)

: 184969-59-3
β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

: 184969-61-7
3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: With Pyridine-2,3-dicarboxylic acid; In dichloromethane; ethyl acetate;

Reference yield:

: 184969-59-3
β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

: 184969-61-7
3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: With dipyridinium dichromate; In dichloromethane;
DOI:10.1016/S0960-894X(01)00709-0

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 184969-61-7
3-(3,4-dichlorophenyl)-1-[[dimethyl(1,1-dimethyl-ethyl)silyl]oxy]-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: Multi-step reaction with 5 steps

1: EDC / CH₂Cl₂

2: LAH / tetrahydrofuran

3: OsO₄; NMO

4: NEt₃ / CH₂Cl₂

5: PDC / CH₂Cl₂

With osmium(VIII) oxide; lithium aluminium tetrahydride; dipyridinium dichromate; N-methyl-2-indolinone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(01)00709-0