β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

Base Information

Chemical Name:β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol
CAS No.:184969-59-3
Molecular Formula:C₂₈H₄₁Cl₂NO₃Si
Molecular Weight:538.63
Hs Code.:

Synonyms:β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

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Chemical Property of β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

Chemical Property:

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Technology Process of β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

There total 6 articles about β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 184969-59-3
β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

Guidance literature:: Multi-step reaction with 4 steps

1: EDC / CH₂Cl₂

2: LAH / tetrahydrofuran

3: OsO₄; NMO

4: NEt₃ / CH₂Cl₂

With osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(01)00709-0

Reference yield:

: 184968-61-4
3-(3,4-di-chlorophenyl)-4-pentenoic acid

: 184969-59-3
β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

Guidance literature:: Multi-step reaction with 4 steps

1: EDC / CH₂Cl₂

2: LAH / tetrahydrofuran

3: OsO₄; NMO

4: NEt₃ / CH₂Cl₂

With osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(01)00709-0

Reference yield:

: 184968-71-6
1-[3-(3,4-dichloro-phenyl)-pent-4-enyl]-4-phenyl-piperidin-4-ol

: 184969-59-3
β-(3,4-dichlorophenyl)-α-[[[dimethyl(1,1-dimethylethyl)silyl]oxy]-methyl]-4-hydroxy-4-phenyl-1-piperidinebutanol

Guidance literature:: Multi-step reaction with 2 steps

1: OsO₄; NMO

2: NEt₃ / CH₂Cl₂

With osmium(VIII) oxide; N-methyl-2-indolinone; triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(01)00709-0