3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

Base Information

Chemical Name:3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester
CAS No.:479218-88-7
Molecular Formula:C₆₄H₈₁ClN₁₂O₁₄S
Molecular Weight:1309.94
Hs Code.:

Synonyms:3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

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Chemical Property of 3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

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Technology Process of 3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

There total 6 articles about 3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 102130-85-8
(3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

: 479218-75-2
Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)-OH

: 479218-88-7
3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 8h; pH=9;

Reference yield:

: 66863-43-2
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid

: 479218-88-7
3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃

2: HCl / ethyl acetate

3: 45 percent / DCC

With hydrogenchloride; caesium carbonate; dicyclohexyl-carbodiimide; In ethyl acetate;
DOI:10.1016/S0960-894X(02)00403-1

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 479218-88-7
3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂SO₄ / H₂O

2: Cs₂CO₃

3: HCl / ethyl acetate

4: 45 percent / DCC

With hydrogenchloride; sulfuric acid; caesium carbonate; dicyclohexyl-carbodiimide; In water; ethyl acetate; 1: Pictet-Spengler condensation;
DOI:10.1016/S0960-894X(02)00403-1