((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

Base Information

Chemical Name:((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride
CAS No.:1131450-87-7
Molecular Formula:C₁₄H₂₀FNO₃S*ClH
Molecular Weight:337.843
Hs Code.:

Synonyms:((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

Suppliers and Price of ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

There total 1 articles about ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 105812-81-5
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

: 1131450-87-7
((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

Guidance literature:: In dichloromethane; at 20 ℃; for 6h;
DOI:10.1124/jpet.115.223768

Reference yield:

: 923932-05-2
benzo[d][1,3]dioxol-(2,2-d2)-5-ol

: 1131450-87-7
((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

: 936838-88-9
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 90 ℃; for 5h;
DOI:10.1124/jpet.115.223768

Reference yield:

: 1131450-87-7
((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methylmethanesulfonate hydrochloride

: 923932-15-4
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 5 h / 90 °C

2.1: N-ethyl-N,N-diisopropylamine / toluene / 5 h / 80 °C

3.1: sodium hydroxide / water; 1,4-dioxane / 3 h / 70 °C

3.2: 1 h / 0 °C

With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; water; toluene;
DOI:10.1124/jpet.115.223768