tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate
• CAS No.: 1146967-61-4
• Molecular Formula: C₁₉H₃₂N₂O₃
• Molecular Weight: 345.403

Synonyms:tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate

Chemical Property of tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate

There total 2 articles about tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methyl-1-propanamine-d9 (1146967-64-7) + (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) → tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate (1146967-61-4)

Guidance literature:

In isopropyl alcohol; at 65 ℃; for 15h;

Reference yield:

2-methyl-1-propanamine-d9 (1146967-64-7) + (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate (1146967-61-4)

Guidance literature:

In isopropyl alcohol; for 6h; Heating / reflux;

Reference yield: 96.0%

tert-butyl (2S,3R)-3-hydroxy-4-((isobutyl-d9)-amino)-1-phenyIbutan-2-ylcarbamate (1146967-61-4) + benzenesulfonyl chloride (98-09-9) → tert-butyl-((2S,3R)-3-hydroxy-4-(N-isobutylphenylsulfonamido)-1-phenylbutan-2-yl)carbamate-d9 (1254047-86-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

upstream raw materials:

2-methyl-1-propanamine-d9

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

Downstream raw materials:

tert-butyl (2S,3R)-3-hydroxy-4-(N-(isobutyl-d9)-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

tert-butyl-((2S,3R)-3-hydroxy-4-(N-isobutylphenylsulfonamido)-1-phenylbutan-2-yl)carbamate-d9

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