2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile

Base Information

• Chemical Name: 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile
• CAS No.: 1239313-10-0
• Molecular Formula: C₂₀H₁₂N₂O
• Molecular Weight: 296.328
• Mol file: 1239313-10-0.mol

Synonyms:2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile

Chemical Property of 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile

There total 3 articles about 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(2-bromophenyl)benzo[d]oxazole (73552-42-8) + 4-cyanophenylboronic acid (126747-14-6) → 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile (1239313-10-0)

Guidance literature:

With nickel(II) chloride hexahydrate; tetrabutyl ammonium fluoride; potassium carbonate; palladium dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;

DOI:10.1021/ol500587m

Reference yield:

2-bromobenzoic acid chloride (7154-66-7) → 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile (1239313-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonic acid / 1,4-dioxane / 5 h / 100 °C

2: tetrabutyl ammonium fluoride; palladium dichloride; nickel(II) chloride hexahydrate; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C

With methanesulfonic acid; nickel(II) chloride hexahydrate; tetrabutyl ammonium fluoride; potassium carbonate; palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;

DOI:10.1021/ol500587m

Reference yield:

2-bromobenzoic-acid (88-65-3) → 2'-(benzoxazol-2-yl)biphenyl-4-carbonitrile (1239313-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuryl dichloride / toluene / 1 h / 80 °C

2: methanesulfonic acid / 1,4-dioxane / 5 h / 100 °C

3: tetrabutyl ammonium fluoride; palladium dichloride; nickel(II) chloride hexahydrate; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C

With sulfuryl dichloride; methanesulfonic acid; nickel(II) chloride hexahydrate; tetrabutyl ammonium fluoride; potassium carbonate; palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 3: |Suzuki-Miyaura Coupling;

DOI:10.1021/ol500587m

upstream raw materials:

2-(2-bromophenyl)benzo[d]oxazole

4-cyanophenylboronic acid

2-bromobenzoic-acid

2-bromobenzoic acid chloride