(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

Base Information

Chemical Name:(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate
CAS No.:1620646-59-4
Molecular Formula:C₂₄H₁₈Cl₃NO₅
Molecular Weight:506.77
Hs Code.:

Synonyms:(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

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Chemical Property of (2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

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Technology Process of (2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

There total 6 articles about (2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4525-65-9
(2,4,6-trichlorophenyl) formate

: 1620646-00-5
2-(3-bromopyridin-4-yl)methyl-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

: 1620646-59-4
(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

Guidance literature:: 2-(3-bromopyridin-4-yl)methyl-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; With tributyl-amine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Sealed tube;

(2,4,6-trichlorophenyl) formate; In toluene; at 110 ℃; Further stages; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1021/acs.jmedchem.7b00702

Reference yield: 31.0%

: 1620646-59-4
(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

Guidance literature:: With tributyl-amine; palladium diacetate; XPhos; In toluene; at 100 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere; Sealed tube;

In toluene; at 100 ℃; for 3h;

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1620646-59-4
(2,4,6-trichlorophenyl) 4-[(5,6-dimethoxy-1-oxo-indan-2-yl)-methyl]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Dean-Stark

2.1: hydrogen; 5 % platinum on carbon / ethanol / 3 h / 20 °C / 760.05 Torr / Reflux; Dean-Stark

3.1: tributyl-amine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / toluene / 0.08 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube

3.2: 110 °C / Inert atmosphere; Schlenk technique; Sealed tube

With tributyl-amine; 5 % platinum on carbon; hydrogen; palladium diacetate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; toluene;
DOI:10.1021/acs.jmedchem.7b00702