4525-65-9Relevant academic research and scientific papers
PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
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Page/Page column 76, (2017/03/21)
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
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Page/Page column 53, (2017/04/11)
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
2-OXO-1,2-DIHYDROPYRIDINE-3,5-DICARBOXAMIDE COMPOUNDS AS BROMODOMAIN INHIBITORS
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Page/Page column 44; 45, (2017/07/29)
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
Palladium-Catalyzed Carbonylative Synthesis of Aryl Formates under Mild Conditions
Jiang, Li-Bing,Li, Rui,Li, Hao-Peng,Qi, Xinxin,Wu, Xiao-Feng
, p. 1788 - 1791 (2016/06/01)
Aryl formates have been extensively applied as CO sources in CO-free carbonylation reactions. However, there are no catalytic synthetic procedures for their preparation. In this manuscript, we developed a convenient palladium-catalyzed procedure for the synthesis of aryl formates. Good yields were achieved under mild reaction conditions with formic acid as the formyl source. A formyl meeting: A convenient palladium-catalyzed carbonylation procedure for the synthesis of aryl formates is developed. Good yields are achieved under mild reaction conditions with formic acid as the formyl source.
Trichlorophenyl formate: Highly reactive and easily accessible crystalline CO surrogate for palladium-catalyzed carbonylation of aryl/alkenyl halides and triflates
Ueda, Tsuyoshi,Konishi, Hideyuki,Manabe, Kei
supporting information, p. 5370 - 5373,4 (2012/12/12)
The high utility of 2,4,6-trichlorophenyl formate, a highly reactive and easily accessible crystalline CO surrogate, is demonstrated. The decarbonylation with NEt3 to generate CO proceeded rapidly at rt, thereby allowing external-CO-free Pd-catalyzed carbonylation of aryl/alkenyl halides and triflates. The high reactivity of the CO surrogate enabled carbonylation at rt and significantly reduced the quantities of formate to near-stoichiometric levels. The obtained trichlorophenyl esters can be readily converted to a variety of carboxylic acid derivatives in high yields.
