2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid

Base Information

• Chemical Name: 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid
• CAS No.: 294855-29-1
• Molecular Formula: C₁₈H₁₄O₆
• Molecular Weight: 326.306
• Mol file: 294855-29-1.mol

Synonyms:2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid

Chemical Property of 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid

There total 2 articles about 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoate → 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid (294855-29-1)

Guidance literature:

With alkali hydroxide; In methanol; at 60 ℃; for 6h; pH=10 - 11; Alkaline conditions;

DOI:10.1080/10286020.2019.1702028

Reference yield:

5,7-dihydroxy-2-phenyl-chromen-4-one (480-40-0) → 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid (294855-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 1 h / 60 °C

1.2: 12 h / 60 °C

2.1: alkali hydroxide / methanol / 6 h / 60 °C / pH 10 - 11 / Alkaline conditions

With potassium carbonate; In methanol; acetone;

DOI:10.1080/10286020.2019.1702028

Reference yield: 60.0%

2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid (294855-29-1) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → N-(2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)isopropionyl)-L-glycine methyl ester

Guidance literature:

2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 4 ℃; for 1h;

glycine ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1080/10286020.2019.1702028

upstream raw materials:

5,7-dihydroxy-2-phenyl-chromen-4-one