BzNH-Tyr(3-Ac)-OMe

Base Information

• Chemical Name: BzNH-Tyr(3-Ac)-OMe
• CAS No.: 158256-96-3
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.364
• Mol file: 158256-96-3.mol

Synonyms:BzNH-Tyr(3-Ac)-OMe

Chemical Property of BzNH-Tyr(3-Ac)-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BzNH-Tyr(3-Ac)-OMe

There total 3 articles about BzNH-Tyr(3-Ac)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzoyl chloride (98-88-4) + methyl (S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoate monohydrochloride (57085-32-2) → BzNH-Tyr(3-Ac)-OMe (158256-96-3)

Guidance literature:

With sodium carbonate; In diethyl ether; water; at 25 ℃; for 0.5h;

Reference yield:

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride (32404-28-7) → BzNH-Tyr(3-Ac)-OMe (158256-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / HCl / 1.5 h / 20 °C

2: 86 percent / Na₂CO₃ / H₂O; diethyl ether / 0.5 h / 25 °C

With hydrogenchloride; sodium carbonate; In diethyl ether; water;

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → BzNH-Tyr(3-Ac)-OMe (158256-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / 1.) AlCl₃, 2.) conc. HCl / nitrobenzene / 6 h / 100 °C

2: 99 percent / HCl

3: 82 percent / Na₂CO₃

With hydrogenchloride; aluminium trichloride; sodium carbonate; In nitrobenzene;

DOI:10.1016/0040-4039(94)85077-1

upstream raw materials:

benzoyl chloride

methyl (S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoate monohydrochloride

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride

L-tyrosine

Refernces

• 1、 Ranganathan,Tamilarasu. "Chemical approaches to protein engineering 20: The transformation of coded amino acid tyrosine to pro-templates having metal uptake potential in peptide/protein segments". . p. 1081 - 1103. Retrieved 2007/10/03.