N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Base Information

Chemical Name:N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide
CAS No.:1227160-47-5
Molecular Formula:C₁₈H₂₄N₆O₂
Molecular Weight:356.428
Hs Code.:

Synonyms:N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Suppliers and Price of N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

There total 8 articles about N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227160-49-7
5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carbonitrile

: 1227160-47-5
N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; for 5h; Reflux;

Reference yield:

: 1225380-89-1
ethyl 1-[3-(tert-butoxycarbonyl)benzyl]-5-methyl-1H-pyrazole-3-carboxylate

: 1227160-47-5
N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

2.2: 16 h / 20 °C

3.1: sodium hydroxide / ethanol / 2 h / 70 °C

3.2: pH Ca_.4

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.2: 1 h / 0 - 20 °C

5.1: trifluoroacetic anhydride / methanol / 1 h / 20 °C

6.1: hydroxylamine hydrochloride; triethylamine / ethanol / 5 h / Reflux

With oxalyl dichloride; hydroxylamine hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trifluoroacetic anhydride; sodium hydroxide; In methanol; ethanol; dichloromethane;

Reference yield:

: 126062-63-3
1,1-dimethylethyl 3-bromomethylbenzoate

: 1227160-47-5
N'-hydroxy-5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboximide amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

3.2: 16 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 70 °C

4.2: pH Ca_.4

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: trifluoroacetic anhydride / methanol / 1 h / 20 °C

7.1: hydroxylamine hydrochloride; triethylamine / ethanol / 5 h / Reflux

With oxalyl dichloride; hydroxylamine hydrochloride; potassium tert-butylate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;