Nitrous Acid

Base Information

• Chemical Name: Nitrous Acid
• CAS No.: 7782-77-6
• Deprecated CAS: 17310-27-9,62498-15-1,62641-25-2,78686-39-2,81744-89-0,88454-09-5,2375630-68-3,62498-15-1,62641-25-2,78686-39-2,81744-89-0,88454-09-5
• Molecular Formula: HN O2
• Molecular Weight: 47.0134
• European Community (EC) Number: 231-963-7
• UNII: T2I5UM75DN
• DSSTox Substance ID: DTXSID7064813
• Nikkaji Number: J4.496B
• Wikipedia: Nitrous acid
• Wikidata: Q207895,Q211891
• ChEMBL ID: CHEMBL1161681
• Mol file: 7782-77-6.mol

Synonyms:Acid, Nitrous;Nitrous Acid

Chemical Property of Nitrous Acid

Chemical Property:

• PKA: pK (25°) 3.35
• PSA: 49.66000
• Density: 1.54±0.1 g/cm3(Predicted)
• LogP: 0.14200
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 47.000728275
• Heavy Atom Count: 3
• Complexity: 10.3

Purity/Quality:

99%, ^*data from raw suppliers

NITROUS ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acids, Inorganic
• Canonical SMILES: N(=O)O
• Uses: Nitrous acid is a diazotizing agent. The acid diazotizes primary aromatic amines to diazo derivatives in manufacturing azo dyes. Nitrous acid is a nitrogen oxoacid. It is a conjugate acid of a nitrite. It (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections. Formation of diazotizing compounds by reaction with primary aromatic amines, source of nitric oxide.
• Description: Nitrous acid (molecular formula?HNO2) is a weak and monobasic acid known only in solution and in the form of nitrite salts. Nitrous acid rapidly decomposes into nitrogen oxide, nitric oxide and water when in solution: 2HNO2 ? NO2 + NO+H2O It can also decompose into nitric acid and nitrous oxide and water. 4HNO2 ? 2HNO3 +N2O +H2O Nitric acid (HNO3), also known as “aqua fortis” and “spirit of nitre”, is a highly corrosive and toxic strong acid that can cause severe burns. It is colorless when pure and a slight yellow when “glacial”. Older samples tend to acquire a yellow cast due to the accumulation of various oxides of nitrogen. If the solution contains more than 86% nitric acid, it is referred to as “fuming nitric acid”.
• Physical properties: Pale blue solution; stable only in solution; weak acid, Ka 4.5x10-4.

Technology Process of Nitrous Acid

There total 310 articles about Nitrous Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + 1-(2-bromo-2-nitrovinyl)-4-nitrobenzene (7559-38-8) → bromonitromethane (563-70-2) + hydrogen bromide (10035-10-6,12258-64-9) + nitric acid (7697-37-2,78989-43-2) + cis-nitrous acid (7782-77-6)

Guidance literature:

Reference yield:

para-dinitrobenzene (100-25-4) + furan-2,3,5(4H)-trione pyridine (1:1) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + cis-nitrous acid (7782-77-6)

Guidance literature:

Reference yield:

water (7732-18-5) + 4-nitro-benzenediazo hydroxide (40078-29-3) → cis-nitrous acid (7782-77-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

upstream raw materials:

nitroso-(1-phenyl-1H-tetrazol-5-yl)-amine

water

1-nitrohydantoin

hydrogenchloride

Downstream raw materials:

Succinimide

4-chloro-2,6-lutidine

ethylene glycol

dilituric acid

Refernces

• 1、 Eyet, Nicole,Shuman, Nicholas S.,Viggiano, Albert A.,Troe, Juergen,Relph, Rachael A.,Steele, Ryan P.,Johnson, Mark A.. "The importance of NO+(H2O)4 in the conversion of NO+(H2O)n to H3O +(H2O)n: I. Kinetics measurements and statistical rate modeling". . p. 7582 - 7590. Retrieved 2011.
• 2、 Plugge, P. C.. "". . p. 173 - 174. Retrieved 1872.
• 3、 Fono, Lorien,Donaldson,Proos, Robert J.,Henry, Bryan R.. "OH overtone spectra and intensities of pernitric acid". . p. 131 - 138. Retrieved 1999.
• 4、 Hellebust, Stig,Roddis, Tristan,Sodeau, John R.. "Potential role of the nitroacidium ion on HONO emissions from the snowpack". . p. 1167 - 1171. Retrieved 2007.
• 5、 Abel, E.,Neusser, E.. "". . . Retrieved 1929.
• 6、 McCoy, Anne B.,Fry, Juliane L.,Francisco, Joseph S.,Mollner, Andrew K.,Okumura, Mitchio. "Role of OH-stretch/torsion coupling and quantum yield effects in the first OH overtone spectrum of cis-cis HOONO". . . Retrieved 2005.
• 7、 Olbert-Majkut, Adriana,Mielke, Zofia. "Infrared matrix isolation and theoretical studies of the hydrogen bonded complexes between nitrous acid and 1,1-dichloroethylene". . p. 689 - 698. Retrieved 2006.
• 8、 Khalizov, Alexei F.,Cruz-Quinones, Miguel,Zhang, Renyi. "Heterogeneous reaction of NO2 on fresh and coated soot surfaces". . p. 7516 - 7524. Retrieved 2010.
• 9、 Jeffery, F. H.. "". . p. 52 - 52. Retrieved 1923.
• 10、 Kenner, R. D.,Rohrer, F.,Stuhl, F.. "OH(A) Production in the 193-nm Photolysis of HONO". . p. 2635 - 2639. Retrieved 1986.