3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

Base Information

Chemical Name:3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one
CAS No.:916755-34-5
Molecular Formula:C₂₈H₂₇BrN₂O₂
Molecular Weight:503.439
Hs Code.:

Synonyms:3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

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Chemical Property of 3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

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Technology Process of 3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

There total 3 articles about 3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 3-benzyloxymethyl-4-(1-ethylpropenyl)-1H-pyridin-2-one

: 35740-83-1
2-bromo-3-bromomethylquinoline

: 916755-34-5
3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

Guidance literature:: With potassium tert-butylate; In 1,2-dimethoxyethane; for 5h; Heating;
DOI:10.1002/ejoc.200600298

Reference yield:

: 3-benzyloxymethyl-4-[(E/Z)-1-ethylpropenyl]-2-methoxypyridine

: 916755-34-5
3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84.4 percent / TMSCl; NaI / acetonitrile / 30 h / 20 °C

2: 86.2 percent / potassium tert-butoxide / 1,2-dimethoxy-ethane / 5 h / Heating

With chloro-trimethyl-silane; potassium tert-butylate; sodium iodide; In 1,2-dimethoxyethane; acetonitrile;
DOI:10.1002/ejoc.200600298

Reference yield:

: 186668-50-8
1-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-1-propanone

: 916755-34-5
3-benzyloxymethyl-1-(2-bromoquinolin-3-ylmethyl)-4-(1-ethylpropenyl)-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: KN(SiMe₃)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 20 °C

1.2: 95.6 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 4 h / -85 - 20 °C

2.1: 84.4 percent / TMSCl; NaI / acetonitrile / 30 h / 20 °C

3.1: 86.2 percent / potassium tert-butoxide / 1,2-dimethoxy-ethane / 5 h / Heating

With chloro-trimethyl-silane; potassium tert-butylate; potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; acetonitrile; 1.1: Wittig reaction;
DOI:10.1002/ejoc.200600298