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186668-50-8

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186668-50-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 186668-50-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,6,6 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 186668-50:
(8*1)+(7*8)+(6*6)+(5*6)+(4*6)+(3*8)+(2*5)+(1*0)=188
188 % 10 = 8
So 186668-50-8 is a valid CAS Registry Number.

186668-50-8Relevant articles and documents

Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates

Peters, Rene,Althaus, Martin,Diolez, Christian,Rolland, Alain,Manginot, Eric,Veyrat, Marc

, p. 7583 - 7595 (2007/10/03)

(Chemical Equation Presented) Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the homocamptothecin derivative diflomotecan 4, are described. The "acetal route" starts from 2-chloro-4

Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

-

, (2008/06/13)

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

-

, (2008/06/13)

A camptothecin analog characterized in that the hydroxy lactone of the camptothecin is a β-hydroxy lactone or the corresponding β-hydroxyacid, resulting from the opening of said lactone, or a derivative of said β-hydroxyacid, or a Pharmaceutically acceptable salt thereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of formulae (I) and (II), pharmaceutical compositions containing said containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoral drugs, are also disclosed.

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