ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

Base Information

Chemical Name:ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride
CAS No.:1612893-63-6
Molecular Formula:C₂₀H₁₉N₅O₄*ClH
Molecular Weight:429.863
Hs Code.:

Synonyms:ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

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Chemical Property of ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

Chemical Property:

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Technology Process of ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

There total 7 articles about ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1612893-55-6
5-(4-guanidinophenyl)isoxazole-3-carboxylic acid hydrochloride

: 94-09-7
p-aminoethylbenzoate

: 1612893-63-6
ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2014.04.118

Reference yield:

: 54808-56-9
4-(4-nitrophenyl)-2,4-dione-butyric acid ethyl ester

: 1612893-63-6
ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride / ethanol / 4 h / Reflux

2: tin(II) chloride dihdyrate / ethyl acetate / 6 h / Reflux

3: hydrogenchloride / ethanol; water / 8 h / Reflux

4: sodium hydroxide / water; methanol / 3 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide / 48 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.118

Reference yield:

: 159670-70-9
ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate

: 1612893-63-6
ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / Reflux

2: hydrogenchloride / ethanol; water / 8 h / Reflux

3: sodium hydroxide / water; methanol / 3 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide / 48 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.118