Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

Base Information

Chemical Name:Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate
CAS No.:1163272-54-5
Molecular Formula:C₂₉H₂₄ClN₅O₆
Molecular Weight:573.992
Hs Code.:

Synonyms:Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

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Chemical Property of Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

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Technology Process of Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

There total 4 articles about Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1163272-51-2
2-Chloro-6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-4-[4-(2-hydroxyethoxy)phenyl]-pyridine-3,5-dicarbonitrile

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 1163272-54-5
Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 948017-31-0
2-Amino-4-[4-(2-hydroxyethoxy)phenyl]-6-(phenylsulfanyl)pyridine-3,5-dicarbonitrile

: 1163272-54-5
Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / 1,2-dimethoxyethane / 10 h / 20 - 60 °C

2: copper dichloride; isopentyl nitrite / acetonitrile / 3 h / 60 °C

3: triethylamine / tetrahydrofuran / 10 h / 20 °C

With potassium tert-butylate; triethylamine; copper dichloride; isopentyl nitrite; In tetrahydrofuran; 1,2-dimethoxyethane; acetonitrile;

Reference yield:

: 22042-73-5
4-(2-hydroxy-ethoxy)-benzaldehyde

: 1163272-54-5
Methyl N-(6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl)-N-methylglycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 2 h / Reflux

1.2: 10 h / 20 °C / Reflux

1.3: 20 - 70 °C

2.1: potassium tert-butylate / 1,2-dimethoxyethane / 10 h / 20 - 60 °C

3.1: copper dichloride; isopentyl nitrite / acetonitrile / 3 h / 60 °C

4.1: triethylamine / tetrahydrofuran / 10 h / 20 °C

With potassium tert-butylate; triethylamine; copper dichloride; isopentyl nitrite; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; acetonitrile;