8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one

Base Information

• Chemical Name: 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one
• CAS No.: 214983-02-5
• Molecular Formula: C₁₅H₁₃N₃OS
• Molecular Weight: 283.354
• Mol file: 214983-02-5.mol

Synonyms:8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one

Chemical Property of 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one

There total 10 articles about 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Ethyl 2-phenylethanoate (101-97-3) + 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) → 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one (214983-02-5)

Guidance literature:

With 40% potassium fluoride/alumina; In N,N-dimethyl acetamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.07.021

Reference yield: 87.0%

N-[8-Methyl-2-methylsulfanyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-(7Z)-ylidene]-acetamide (214983-25-2) → 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one (214983-02-5)

Guidance literature:

With hydrogenchloride; for 0.0833333h; Heating;

DOI:10.1021/jm980398y

Reference yield: 55.0%

8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine (214983-00-3) → 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one (214983-02-5)

Guidance literature:

With acetic anhydride; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113252

upstream raw materials:

N-[8-Methyl-2-methylsulfanyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-(7Z)-ylidene]-acetamide

Ethyl 2-phenylethanoate

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

8-methyl-2-(methylsulfonyl)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-one