8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine

Base Information

• Chemical Name: 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine
• CAS No.: 214983-00-3
• Molecular Formula: C₁₅H₁₄N₄S
• Molecular Weight: 282.369
• Mol file: 214983-00-3.mol

Synonyms:8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine

Chemical Property of 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine

There total 5 articles about 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

phenylacetonitrile (140-29-4) + 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) → 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine (214983-00-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2021.113252

Reference yield: 54.0%

→ 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine (214983-00-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 105 ℃; for 18h; Inert atmosphere;

Reference yield:

4-methylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester (76360-82-2) → 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-imine (214983-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Reflux

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2021.113252

upstream raw materials:

phenylacetonitrile

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

4-methylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

(4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

Downstream raw materials:

N-[8-Methyl-2-methylsulfanyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-(7Z)-ylidene]-acetamide

8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-(8H)-one

8-methyl-2-(methylsulfonyl)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-one