{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

Base Information

Chemical Name:{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester
CAS No.:788824-17-9
Molecular Formula:C₂₃H₁₇Br₂F₃O₅
Molecular Weight:590.188
Hs Code.:

Synonyms:{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

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Chemical Property of {3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

Chemical Property:

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Technology Process of {3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

There total 6 articles about {3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 788824-16-8
C₁₆H₁₄Br₂O₅

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 788824-17-9
{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 100-66-3
methoxybenzene

: 788824-17-9
{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: I₂; HNO₃; Ac₂O / TFA

1.2: aq. NaBF₄

2.1: Cu; Et₃N / CH₂Cl₂

3.1: SnCl₄ / CH₂Cl₂ / 0 °C

4.1: H₂O₂; H₂SO₄ / methanol

4.2: Cu(OAc)2; Et₃N / CH₂Cl₂

With sulfuric acid; dihydrogen peroxide; iodine; nitric acid; acetic anhydride; tin(IV) chloride; copper; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.04.032

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 788824-17-9
{3,5-dibromo-4-[4-methoxy-3-(4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. Br₂ / 20 °C

2.1: Cu; Et₃N / CH₂Cl₂

3.1: SnCl₄ / CH₂Cl₂ / 0 °C

4.1: H₂O₂; H₂SO₄ / methanol

4.2: Cu(OAc)2; Et₃N / CH₂Cl₂

With sulfuric acid; dihydrogen peroxide; bromine; tin(IV) chloride; copper; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.04.032