3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Name:3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1584715-39-8
Molecular Formula:C₂₃H₁₇BrClN₅O₂
Molecular Weight:510.777
Hs Code.:

Synonyms:3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 4 articles about 3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

: 1584715-38-7
9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: 9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃; for 2h;

With acetic acid; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1584715-37-6
9-bromo-5-(4-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 16 h / 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1584716-02-8
2-bromo-N-(2-bromo-6-(4-chlorobenzoyl)phenyl)acetamide

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 16 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

3.2: 2 h / -78 °C

3.3: 16 h / 20 °C

With ammonia; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;