(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate
CAS No.:1584715-42-3
Molecular Formula:C₃₀H₃₂BrClF₃N₃O₄
Molecular Weight:670.954
Hs Code.:

(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

Synonyms:(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

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Chemical Property of (2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

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Technology Process of (2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

There total 16 articles about (2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 1581735-04-7
(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: 1584715-41-2
3-amino-9-bromo-5-(4-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-42-3
(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1584715-37-6
9-bromo-5-(4-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-42-3
(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 16 h / 20 °C

3.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

4.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With trifluorormethanesulfonic acid; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1584715-38-7
9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-42-3
(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 2 h / -78 °C

1.3: 16 h / 20 °C

2.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

3.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With trifluorormethanesulfonic acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide;