(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate
CAS No.:1584715-89-8
Molecular Formula:C₃₃H₃₇ClF₃N₃O₄
Molecular Weight:632.123
Hs Code.:

(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

Synonyms:(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

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Chemical Property of (2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

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Technology Process of (2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

There total 18 articles about (2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1104637-36-6
cyclopropylboronic acid methyliminodiacetic acid ester

: 1584715-42-3
(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

: 1584715-89-8
(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

: 1584715-91-2
(2S,3R)-tert-butyl 3-((3R)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: cyclopropylboronic acid methyliminodiacetic acid ester; (2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate; With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 90 - 100 ℃; for 5h; Inert atmosphere;

In methanol; carbon dioxide; Supercritical conditions; liquid CO₂;

Reference yield:

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-89-8
(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

: 1584715-91-2
(2S,3R)-tert-butyl 3-((3R)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

2.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

4.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

With potassium phosphate; trifluorormethanesulfonic acid; palladium diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1584715-40-1
3-amino-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-89-8
(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

: 1584715-91-2
(2S,3R)-tert-butyl 3-((3R)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

3.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

With potassium phosphate; trifluorormethanesulfonic acid; palladium diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; trifluoroacetic acid; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; toluene;