1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

Base Information

Chemical Name:1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one
CAS No.:1253176-60-1
Molecular Formula:C₃₄H₄₁NO₅
Molecular Weight:543.703
Hs Code.:

Synonyms:1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

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Chemical Property of 1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

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Technology Process of 1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

There total 3 articles about 1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1072879-63-0
N-phenylmethylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methylamine

: 188406-86-2
1-diazo-4-(2-methyl-1,3-dioxolan-2-yl)butan-2-one

: 1253176-60-1
1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

Guidance literature:: With C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾; In toluene; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol102064b

Reference yield:

: 4388-57-2
tert-butyldimethylsilyl 3-(2-methyl-1,3-dioxolan-2-yl)propanoate

: 1253176-60-1
1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C / Inert atmosphere

2: acetonitrile / 24 h / 0 °C / Inert atmosphere

3: C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾ / toluene / 24 h / 25 °C / Inert atmosphere

With oxalyl dichloride; C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol102064b

Reference yield:

: 65251-82-3
3-(2-Methyl-[1,3]dioxolan-2-yl)-propionyl chloride

: 1253176-60-1
1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 0 °C / Inert atmosphere

2: C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾ / toluene / 24 h / 25 °C / Inert atmosphere

With C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾; In toluene; acetonitrile;
DOI:10.1021/ol102064b