2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

Base Information

Chemical Name:2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile
CAS No.:1074764-01-4
Molecular Formula:C₃₀H₃₄N₂
Molecular Weight:422.613
Hs Code.:

Synonyms:2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

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Chemical Property of 2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

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Technology Process of 2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

There total 3 articles about 2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 78-82-0
Isobutyronitrile

: 1074763-45-3
(2R)-N-benzyl-8-bromo-5-methyl-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydronaphthalen-2-amine

: 1074764-01-4
2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

Guidance literature:: Isobutyronitrile; With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 20 ℃; for 0.166667h;

(2R)-N-benzyl-8-bromo-5-methyl-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydronaphthalen-2-amine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene; at 100 ℃;

Reference yield:

: 951155-03-6
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

: 1074764-01-4
2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / 20 °C

2.2: 100 °C

With sodium hexamethyldisilazane; potassium carbonate; potassium iodide; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 100-39-0
benzyl bromide

: 1074764-01-4
2-[(7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / 20 °C

2.2: 100 °C

With sodium hexamethyldisilazane; potassium carbonate; potassium iodide; In tetrahydrofuran; toluene; acetonitrile;