1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil

Base Information

• Chemical Name: 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil
• CAS No.: 159042-27-0
• Molecular Formula: C₁₉H₁₉FN₂O₇
• Molecular Weight: 406.367
• Mol file: 159042-27-0.mol

Synonyms:1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil

Chemical Property of 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil

There total 8 articles about 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-phenyluracil (15761-83-8) → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil (159042-27-0)

Guidance literature:

Multi-step reaction with 4 steps

1: (NH₄)2SO₄ / 2 h / Heating

2: 40 percent / CH₂Cl₂ / 120 h / Ambient temperature

3: NH₃, MeOH / 48 h / Ambient temperature

4: pyridine

With pyridine; methanol; ammonium sulfate; ammonia; In dichloromethane;

DOI:10.1080/15257779408013228

Reference yield:

5-phenyl-2,4,6-pyrimidinetrione (22275-34-9) → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil (159042-27-0)

Guidance literature:

Multi-step reaction with 5 steps

2: (NH₄)2SO₄ / 2 h / Heating

3: 40 percent / CH₂Cl₂ / 120 h / Ambient temperature

4: NH₃, MeOH / 48 h / Ambient temperature

5: pyridine

With pyridine; methanol; ammonium sulfate; ammonia; In dichloromethane;

DOI:10.1080/15257779408013228

Reference yield:

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide (56632-81-6) → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil (159042-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / CH₂Cl₂ / 120 h / Ambient temperature

2: NH₃, MeOH / 48 h / Ambient temperature

3: pyridine

With pyridine; methanol; ammonia; In dichloromethane;

DOI:10.1080/15257779408013228

upstream raw materials:

acetic anhydride

5-phenyluracil

5-phenyl-2,4,6-pyrimidinetrione

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide

Downstream raw materials:

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(p-nitrophenyl)cytosine

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(o-aminophenyl)uracil

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(o-aminophenyl)cytosine