N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

Base Information

Chemical Name:N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide
CAS No.:1310048-39-5
Molecular Formula:C₂₄H₂₅N₅O₅
Molecular Weight:463.493
Hs Code.:

Synonyms:N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

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Chemical Property of N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

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Technology Process of N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

There total 6 articles about N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1310048-52-2
N-(3-azidopropyl)-4-((4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)phenoxy)methyl)benzamide

: 1310048-39-5
N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

Guidance literature:: With ammonium cerium (IV) nitrate; water; In acetonitrile; at 95 ℃; for 3h; Inert atmosphere;
DOI:10.1002/anie.201007871

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1310048-39-5
N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: potassium tert-butylate; water / diethyl ether / 48 h / Inert atmosphere

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: ammonium cerium (IV) nitrate; water / acetonitrile / 3 h / 95 °C / Inert atmosphere

With dmap; ammonium cerium (IV) nitrate; potassium tert-butylate; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201007871

Reference yield:

: 1039921-05-5
methyl 4-[(4'-aminophenoxy)methyl]benzoate

: 1310048-39-5
N-(3-azidopropyl)-4-((4-(3,5-dioxocyclohexanecarboxamido)phenoxy)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate; water / diethyl ether / 48 h / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

4: ammonium cerium (IV) nitrate; water / acetonitrile / 3 h / 95 °C / Inert atmosphere

With dmap; ammonium cerium (IV) nitrate; potassium tert-butylate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201007871