Iopamidol

Base Information

• Chemical Name: Iopamidol
• CAS No.: 62883-00-5
• Molecular Formula: C₁₇H₂₂I₃N₃O₈
• Molecular Weight: 777.09
• Hs Code.: 2924299090
• Mol file: 62883-00-5.mol

Synonyms:1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-(9CI);N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarboxamide;

Chemical Property of Iopamidol

Chemical Property:

• Boiling Point: 785.3 °C at 760 mmHg
• PKA: pKa 10.70(H2O,t = 25.0) (Uncertain)
• Flash Point: 428.8 °C
• PSA: 188.45000
• Density: 2.281 g/cm³
• LogP: -0.15950
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Water (Slightly)

Purity/Quality:

Above 99% ^*data from raw suppliers

Iopamidol European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diagnostic aid (radiopaque medium. Iopamidol (CAS# 60208-45-9) is a radiological nonionic medical contrast agent.

Technology Process of Iopamidol

There total 20 articles about Iopamidol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-(acetyloxy)-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide → Iopamidol (60166-93-0,60208-45-9,62883-00-5)

Guidance literature:

With sodium hydroxide; for 0.166667h;

Reference yield: 95.0%

(S)-5-(2-amino-1-methyl-2-oxoethoxy)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide → Iopamidol (60166-93-0,60208-45-9,62883-00-5)

Guidance literature:

With Amberlite IRA₄₀₀; In water; for 32h; pH=6 - 7; Product distribution / selectivity;

Reference yield: 94.0%

S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride (60166-91-8) + serinol (534-03-2) → Iopamidol (60166-93-0,60208-45-9,62883-00-5)

Guidance literature:

In ISOPROPYLAMIDE; at 8 - 20 ℃; for 10h;

upstream raw materials:

S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride

serinol

2,4,6-triiodo-5-aminoisophthalic acid

5-nitrobenzene-1,3-dicarboxylic acid

Refernces

• 1、 -. "MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES". Page/Page column 21; 22; 23; 24; 25; 26. . Retrieved 2018/06/30.
• 2、 -. "Manufacture of a Triiodinated Contrast Agent". Paragraph 0031-0035. . Retrieved 2014/06/23.