4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol

Base Information

• Chemical Name: 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol
• CAS No.: 851609-11-5
• Molecular Formula: C₂₃H₃₀F₂O₄SSi
• Molecular Weight: 468.637

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol

Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol

There total 1 articles about 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-but-2-ene-1,4-diol (851609-10-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol (851609-11-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol (851609-11-5) + acetyl chloride (75-36-5) → acetic acid 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-enyl ester (851609-12-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 12h;

Reference yield:

4-acetoxy-2-(3,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-but-2-enoic acid (851609-13-7) + 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol (851609-11-5) → 4-acetoxy-2-(3,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-but-2-enoic acid 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-enylester (851609-14-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 1h;

upstream raw materials:

2-(3,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-but-2-ene-1,4-diol

tert-butyldimethylsilyl chloride

Downstream raw materials:

acetic acid 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-enyl ester

4-acetoxy-2-(3,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-but-2-enoic acid 4-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-difluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-but-2-enylester

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