2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

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Chemical Name:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester
CAS No.:195310-61-3
Molecular Formula:C₂₉H₂₉Cl₃N₂O₇
Molecular Weight:623.917
Hs Code.:

2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid <i>tert</i>-butyl ester 2,2,2-trichloro-ethyl ester

Synonyms:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

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Chemical Property of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

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Technology Process of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

There total 6 articles about 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 195309-02-5
[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-acetic acid tert-butyl ester

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 195310-61-3
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

Guidance literature:: [2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-acetic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

2,2,2-Trichloroethyl chloroformate; In tetrahydrofuran;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: (3-phenyl-allylideneamino)-acetic acid tert-butyl ester

: 195310-61-3
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: 56 percent / tetrahydrofuran

With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 195310-61-3
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: desiccating agent / CH₂Cl₂ / 20 °C

2.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3.2: 56 percent / tetrahydrofuran

With desiccating agent; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031