(2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

Base Information

Chemical Name:(2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate
CAS No.:1338801-20-9
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:(2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

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Chemical Property of (2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

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Technology Process of (2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

There total 2 articles about (2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 1121-60-4
pyridine-2-carbaldehyde

: 623-73-4
diazoacetic acid ethyl ester

: 1072879-54-9
3,3',5,5'-tetramethyl-4,4'-dimethoxy benzhydrylamine

: 1338801-20-9
(2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

Guidance literature:: 3,3',5,5'-tetramethyl-4,4'-dimethoxy benzhydrylamine; With triphenylborane; (R)-t-Bu₂VANOL; In toluene; at 80 ℃; for 0.5h; Inert atmosphere;

pyridine-2-carbaldehyde; diazoacetic acid ethyl ester; In toluene; at 25 ℃; for 24h; stereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/ejoc.201301766

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 623-73-4
diazoacetic acid ethyl ester

: C₁₉H₂₅NO₂*C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾

: 1338801-20-9
(2R,3S)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(pyridin-2-yl)aziridine-2-carboxylate

Guidance literature:: In toluene; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ol202472z