5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester

Base Information

• Chemical Name: 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester
• CAS No.: 1192319-26-8
• Molecular Formula: C₁₉H₂₀N₂O₇
• Molecular Weight: 388.377
• Mol file: 1192319-26-8.mol

Synonyms:5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester

Chemical Property of 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester

There total 3 articles about 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methyl 5-fluoro-2-nitrobenzoate (393-85-1) + tert-butyl 3-hydroxyphenylcarbamate (19962-06-2) → 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester (1192319-26-8)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In DMF (N,N-dimethylformamide); at 20 ℃; for 72h;

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester (1192319-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 50 h / 20 °C / Reflux

2: 18-crown-6 ether; potassium carbonate / DMF (N,N-dimethylformamide) / 72 h / 20 °C

With 18-crown-6 ether; potassium carbonate; In DMF (N,N-dimethylformamide); acetone;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + m-Hydroxyaniline (591-27-5) → 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester (1192319-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 72 h / 20 °C

2: 18-crown-6 ether; potassium carbonate / DMF (N,N-dimethylformamide) / 72 h / 20 °C

With 18-crown-6 ether; potassium carbonate; In DMF (N,N-dimethylformamide); ethanol;

upstream raw materials:

methyl 5-fluoro-2-nitrobenzoate

tert-butyl 3-hydroxyphenylcarbamate

di-tert-butyl dicarbonate

m-Hydroxyaniline