(2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol

Base Information

• Chemical Name: (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol
• CAS No.: 113965-65-4
• Molecular Formula: C₁₀H₁₁F₃O₂S
• Molecular Weight: 252.257
• Mol file: 113965-65-4.mol

Synonyms:(2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol

Chemical Property of (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol

There total 5 articles about (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1,1,1-Trifluoro-3-((R)-toluene-4-sulfinyl)-propane-2,2-diol (105984-83-6) → (2S,RS)-1-(4-methylphenyl)sulfinyl-3,3,3-trifluoropropan-2-ol (113965-66-5) + (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol (113965-65-4)

Guidance literature:

With 4 Angstroems MS; diisobutylaluminium hydride; Product distribution; other reagent;

DOI:10.1021/jo981294y

Reference yield:

1,1,1-Trifluoro-3-((R)-toluene-4-sulfinyl)-propan-2-one (113965-64-3) → (2S,RS)-1-(4-methylphenyl)sulfinyl-3,3,3-trifluoropropan-2-ol (113965-66-5) + (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol (113965-65-4)

Guidance literature:

With ammonium hydroxide; lithium borohydride; In methanol; at -40 ℃; for 0.0833333h; Yield given. Yields of byproduct given;

DOI:10.1055/s-1988-27764

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) → (2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol (113965-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiN(Pr-i)2 / tetrahydrofuran / -78 °C

2: NaBH₄ / ethanol / 0 °C

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1039/c39870001340

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

lithium trifluoroacetate

1,1,1-Trifluoro-3-((R)-toluene-4-sulfinyl)-propan-2-one

1,1,1-Trifluoro-3-((R)-toluene-4-sulfinyl)-propane-2,2-diol

Downstream raw materials:

(R)-1,1,1-Trifluoro-3-p-tolylsulfanyl-propan-2-ol

(R)-1-2,2,2-Trifluoro-1-(p-tolylthiomethyl)ethyl hydrogen phthalate

(R)-2-Phenyl-propionic acid (R)-2,2,2-trifluoro-1-p-tolylsulfanylmethyl-ethyl ester

(S)-2-Phenyl-propionic acid (R)-2,2,2-trifluoro-1-p-tolylsulfanylmethyl-ethyl ester