4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde

Base Information

• Chemical Name: 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde
• CAS No.: 351416-11-0
• Molecular Formula: C₁₉H₁₆N₂O₃
• Molecular Weight: 320.348
• Mol file: 351416-11-0.mol

Synonyms:4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde

Chemical Property of 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde

There total 2 articles about 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-formylphenylboronic acid, (87199-17-5) + 5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one (247158-79-8) → 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde (351416-11-0)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; Heating;

DOI:10.1055/s-2001-13409

Reference yield:

5-bromo-6-phenylpyridazin-3(2H)-one (90766-97-5) → 4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde (351416-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 4-DMAP; iPr₂NEt / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 92 percent / K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; toluene; 2: Suzuki cross-coupling reaction;

DOI:10.1055/s-2001-13409

Reference yield: 90.0%

4-(1-methoxymethyl-6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde (351416-11-0) → 4-(6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde (351416-15-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Heating;

DOI:10.1055/s-2001-13409

upstream raw materials:

4-formylphenylboronic acid,

5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one

5-bromo-6-phenylpyridazin-3(2H)-one

Downstream raw materials:

4-(6-oxo-3-phenyl-1,6-dihydro-pyridazin-4-yl)-benzaldehyde