2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine

Base Information

• Chemical Name: 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine
• CAS No.: 1000197-88-5
• Molecular Formula: C₁₀H₅F₈N
• Molecular Weight: 291.144
• Mol file: 1000197-88-5.mol

Synonyms:2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine

Chemical Property of 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine

There total 1 articles about 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,2,3,3,3-pentafluoropropyl amine (422-03-7) + 2,4,6-trifluorobenzaldehyde (58551-83-0) → 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine (1000197-88-5)

Guidance literature:

In toluene; Reflux; Dean-Stark;

DOI:10.1016/j.bmc.2015.08.038

Reference yield: 14.0%

2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine (1000197-88-5) + trimethylsilyl cyanide (7677-24-9) → 2,4,6-trifluoro-α-[(2,2,3,3,3-pentafluoropropyl)amino]benzeneacetonitrile (1000197-89-6)

Guidance literature:

With zinc(II) iodide; In dichloromethane; Molecular sieve; Reflux;

DOI:10.1016/j.bmc.2015.08.038

Reference yield:

2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine (1000197-88-5) → 3,5-dichloro-1-(2,2,3,3,3-pentafluoropropyl)-6-(2,4,6-trifluorophenyl)-2(1H)-pyrazinone

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc(II) iodide / dichloromethane / Molecular sieve; Reflux

2.1: chlorobenzene / 100 °C

2.2: 100 °C

With zinc(II) iodide; In dichloromethane; chlorobenzene;

DOI:10.1016/j.bmc.2015.08.038

upstream raw materials:

2,2,3,3,3-pentafluoropropyl amine

2,4,6-trifluorobenzaldehyde

Downstream raw materials:

2,4,6-trifluoro-α-[(2,2,3,3,3-pentafluoropropyl)amino]benzeneacetonitrile