1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

Base Information

Chemical Name:1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone
CAS No.:444664-05-5
Molecular Formula:C₂₀H₁₂Cl₂F₂N₂O₂
Molecular Weight:421.23
Hs Code.:

Synonyms:1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

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Chemical Property of 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property:

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Technology Process of 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

There total 7 articles about 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444663-88-1
1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

: 444664-05-5
1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

Guidance literature:: With boron tribromide;
DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

: 14542-71-3
2,6-dibromo-4-methoxytoluene

: 444664-05-5
1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 7 steps

1: NBS; Bz₂O₂

2: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

3: TFA / Heating

4: Pd(PPh₃)4

5: BBr₃

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In N,N-dimethyl-formamide; 4: Ullmann coupling / 6: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

: 130445-13-5
1,3-dibromo-2-(bromomethyl)-5-methoxybenzene

: 444664-05-5
1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-3,4-dihydro-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 6 steps

1: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

2: TFA / Heating

3: Pd(PPh₃)4

4: BBr₃

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide; 3: Ullmann coupling / 5: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00752-7