N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine

Base Information

• Chemical Name: N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine
• CAS No.: 444663-76-7
• Molecular Formula: C₁₆H₁₇Br₂NO₂
• Molecular Weight: 415.124
• Mol file: 444663-76-7.mol

Synonyms:N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine

Chemical Property of N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine

There total 2 articles about N-(2,6-dibromo-4-methoxybenzyl)(4-methoxyphenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dibromo-4-methoxytoluene (14542-71-3) → (2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine (444663-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS; Bz₂O₂

With N-Bromosuccinimide; dibenzoyl peroxide;

DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

1,3-dibromo-2-(bromomethyl)-5-methoxybenzene (130445-13-5) + 4-methoxy-benzylamine (2393-23-9) → (2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine (444663-76-7)

Guidance literature:

DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

(2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine (444663-76-7) → 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one

Guidance literature:

Multi-step reaction with 9 steps

1: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

2: TFA / Heating

3: Pd(PPh₃)4

4: BBr₃

5: Pd(PPh₃)4; LiCl

6: H₂ / PtO₂

7: TFA

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; boron tribromide; potassium carbonate; trifluoroacetic acid; lithium chloride; platinum(IV) oxide; In N,N-dimethyl-formamide; 2: Ullmann coupling / 4: Suzuki coupling / 7: Stille coupling;

DOI:10.1016/S0960-894X(02)00752-7

upstream raw materials:

1,3-dibromo-2-(bromomethyl)-5-methoxybenzene

4-methoxy-benzylamine

2,6-dibromo-4-methoxytoluene

Downstream raw materials:

N-[(2,6-dibromo-4-methoxyphenyl)methyl]-N'-(2,6-dichlorophenyl)-N-[(4-methoxyphenyl)methyl]urea

1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2-chlorophenyl)-7-hydroxy-3,4-dihydro-2(1 H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone