2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

Base Information

Chemical Name:2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester
CAS No.:219657-67-7
Molecular Formula:C₃₁H₃₂N₂O₆
Molecular Weight:528.605
Hs Code.:

Synonyms:2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

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Chemical Property of 2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

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Technology Process of 2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

There total 6 articles about 2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75-03-6
ethyl iodide

: 196811-12-8
2(S)-(1-(methoxycarbonyl)-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid

: 219657-67-7
2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm980414r

Reference yield:

: 41302-34-5
2-(methoxycarbonyl)cyclohexanone

: 219657-67-7
2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 16 h / Heating

2: anisole / 10 percent Pd/C / 6 h / 190 °C

3: 1M aq. LiOH / tetrahydrofuran; ethanol / 30 h

4: 37 percent / conc. aq. HCl / methanol / 4 h / 70 °C

5: 85 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; potassium carbonate; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm980414r

Reference yield:

: 196811-04-8
(S)-amino-3-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>propionic acid methyl ester

: 219657-67-7
2-((S)-1-Methoxycarbonyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethylamino)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 16 h / Heating

2: anisole / 10 percent Pd/C / 6 h / 190 °C

3: 1M aq. LiOH / tetrahydrofuran; ethanol / 30 h

4: 37 percent / conc. aq. HCl / methanol / 4 h / 70 °C

5: 85 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; potassium carbonate; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm980414r