diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate

Base Information

• Chemical Name: diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate
• CAS No.: 86397-86-6
• Molecular Formula: C₁₈H₂₀ClNO₄
• Molecular Weight: 349.814
• Mol file: 86397-86-6.mol

Synonyms:diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate

Chemical Property of diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate

There total 6 articles about diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate (86397-86-6)

Guidance literature:

With manganese(III) triacetate dihydrate; at 20 ℃; for 1h; Milling;

DOI:10.1016/j.tetlet.2017.01.016

Reference yield: 70.0%

ethyl 3-((4-chlorophenyl)amino)but-2-enoate (41014-75-9) → diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate (86397-86-6)

Guidance literature:

With [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; In dichloromethane; at 0 - 10 ℃; for 2h;

DOI:10.1055/s-0029-1217743

Reference yield: 56.0%

(Z)-3-(4-chloro-phenylamino)-but-2-enoic acid ethyl ester (66558-25-6) → diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate (86397-86-6)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1081/SCC-100103979

upstream raw materials:

(Z)-3-(4-chloro-phenylamino)-but-2-enoic acid ethyl ester

ethyl acetoacetate

4-chloro-aniline

ethyl 3-((4-chlorophenyl)amino)but-2-enoate