3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Base Information

Chemical Name:3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile
CAS No.:1253431-45-6
Molecular Formula:C₁₉H₂₂ClN₃O
Molecular Weight:343.856
Hs Code.:

Synonyms:3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

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Chemical Property of 3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

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Technology Process of 3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

There total 8 articles about 3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 3288-99-1
4-tert-butylbenzyl cyanide

: 1253433-80-5
methyl 4-chloro-1-ethyl-3-methyl-1H-pyrazole-5-carboxylate

: 1253431-45-6
3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Guidance literature:: 4-tert-butylbenzyl cyanide; methyl 4-chloro-1-ethyl-3-methyl-1H-pyrazole-5-carboxylate; In 2-ethoxy-ethanol; n-heptane; for 1h; Inert atmosphere; Reflux;

With sodium methylate; In methanol; 2-ethoxy-ethanol; n-heptane; for 4h; Inert atmosphere; Reflux;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield:

: 3288-99-1
4-tert-butylbenzyl cyanide

: 128537-47-3
1-ethyl-3-methyl-4-chloro-5-pyrazolecarboxylic acid ethyl ester

: 1253431-45-6
3-(4-chloro-1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Guidance literature:: 4-tert-butylbenzyl cyanide; 1-ethyl-3-methyl-4-chloro-5-pyrazolecarboxylic acid ethyl ester; In n-heptane; 2-methoxy-ethanol; for 1h; Reflux;

With sodium methylate; In n-heptane; 2-methoxy-ethanol; for 5h; Reflux;
DOI:10.1002/jhet.2682