METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE
• CAS No.: 88398-73-6
• Molecular Formula: C8H12 N2 O2
• Molecular Weight: 168.195
• Hs Code.: 2933199090
• Mol file: 88398-73-6.mol

Synonyms:METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE;METHYL 1-ETHYL-3-METHYLPYRAZOLE-5-CARBOXYLATE

Chemical Property of METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: n20/D 1.485
• Boiling Point: 257.1°C at 760 mmHg
• PKA: 0.96±0.10(Predicted)
• Flash Point: 87°C
• PSA: 44.12000
• Density: 1.12g/cm³
• LogP: 0.99800

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl 1-ethyl-3-methyl-1H-pyrazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

There total 4 articles about METHYL 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid (50920-65-5) → methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate (88398-73-6)

Guidance literature:

With thionyl chloride; at 80 ℃;

Reference yield: 73.2%

Dimethyl oxalate (553-90-2) + diethyl sulfate (64-67-5) + acetone (67-64-1) → methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate (88398-73-6)

Guidance literature:

Dimethyl oxalate; acetone; With sodium methylate; In methanol; at -5 - 5 ℃;

diethyl sulfate; With hydrazinium sulfate; In methanol; toluene; at 130 ℃;

Reference yield:

methyl 2,4-dioxopentanoate (20577-61-1) → methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate (88398-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / dichloromethane

2: dichloromethane

With hydrazine hydrate; In dichloromethane;

DOI:10.1021/acs.jafc.6b04221

upstream raw materials:

diethyl sulfate

3-methyl-1H-pyrazole-5-carboxylic acid methyl ester

methyl 2,4-dioxopentanoate

Dimethyl oxalate

Downstream raw materials:

C₂₄H₃₁N₃O₂

Z-2-(4-(tert-butyl)phenyl)-2-cyano-1-(1-ethyl-3-methyl-1H-5-pyrazolyl)vinyl pivalate

C₂₄H₃₀FN₃O₂

C₂₄H₃₀BrN₃O₂