ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Base Information

Chemical Name:ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride
CAS No.:1541199-27-2
Molecular Formula:C₁₇H₂₁ClN₂O₃*ClH
Molecular Weight:373.279
Hs Code.:

Synonyms:ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

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Chemical Property of ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

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Technology Process of ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

There total 10 articles about ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1541199-28-3
(S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoic acid

: 1541199-27-2
ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; for 6h; Reflux; Inert atmosphere;

Reference yield:

: 1541198-29-1
C₁₅H₁₈ClNO₄

: 1541199-27-2
ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / Heating

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.32 / Enzymatic reaction

4.2: 0.25 h / 20 °C

5.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In ethanol; dichloromethane; water; acetone;

Reference yield:

: 1541198-28-0
C₁₅H₁₇ClO₅

: 1541199-27-2
ethyl (S)-3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert-butyl chloroformate; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / ethanol / 7 h / Heating

5.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.32 / Enzymatic reaction

5.2: 0.25 h / 20 °C

6.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; toluene-4-sulfonic acid; tert-butyl chloroformate; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;