2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Base Information

Chemical Name:2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate
CAS No.:1380347-90-9
Molecular Formula:C₂₀H₂₃F₃N₄O₆
Molecular Weight:472.421
Hs Code.:

Synonyms:2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Suppliers and Price of 2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

There total 10 articles about 2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 75-89-8
2,2,2-trifluoroethanol

: 1380347-88-5
3-(1-benzyl-3-nitro-1H-pyrazol-4-yl )-N-(tert-butoxycarbonyl )-Lalanine

: 1380347-90-9
2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; for 18h;

Reference yield:

: 1380347-81-8
(1-benzyl-3-nitro-1H-pyrazol-4-yl)methanol

: 1380347-90-9
2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 5 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 18 h / 20 °C

2: cesiumhydroxide monohydrate; O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide / dichloromethane / 18 h / -30 °C

3: trifluoroacetic acid / dichloromethane / 66 h

4: sodium hydroxide / water; tetrahydrofuran / 18 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 18 h

With cesiumhydroxide monohydrate; carbon tetrabromide; O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; dmap; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1380347-82-9
1-benzyl-4-(bromomethyl)-3-nitro-1H-pyrazole

: 1380347-90-9
2,2,2-trifluoroethyl 3-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1: cesiumhydroxide monohydrate; O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide / dichloromethane / 18 h / -30 °C

2: trifluoroacetic acid / dichloromethane / 66 h

3: sodium hydroxide / water; tetrahydrofuran / 18 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 18 h

With cesiumhydroxide monohydrate; O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; dmap; In tetrahydrofuran; dichloromethane; water;