(2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

Base Information

Chemical Name:(2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate
CAS No.:1234367-62-4
Molecular Formula:C₃₅H₄₀ClN₇O₁₁
Molecular Weight:770.196
Hs Code.:

Synonyms:(2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

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Chemical Property of (2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

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Technology Process of (2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

There total 1 articles about (2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1234367-61-3
C₃₄H₃₆Cl₂N₄O₁₁

: 113-00-8
guanidine nitrate

: 1234367-62-4
(2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In 1-methyl-pyrrolidin-2-one; at 30 ℃; for 1.5h;

Reference yield: 45.0%

: 1234367-62-4
(2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate

: 76-05-1
trifluoroacetic acid

: 2-(6-chloro-4-(3-(4-((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl)piperazin-1-yl)phenyl)quinazolin-2-yl)guanidine trifluoroacetate

Guidance literature:: (2R,3R,4S,5R)-6-(-(3-(6-chloro-2-(diaminomethyleneamino)quinazolin-4-yl)phenyl)piperazin-1-yl)-6-oxohexane-1,2,3,4,5-pentayl pentaacetate; With water; lithium hydroxide; In methanol; at 0 ℃; for 0.5h;

With hydrogenchloride; In methanol; water; pH=7;

trifluoroacetic acid;