Technology Process of 2-ethenyl-3,4,6-trimethoxybenzoic acid
There total 4 articles about 2-ethenyl-3,4,6-trimethoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
3-hydroxy-4,5,7-trimethoxy-1(3H)-isobenzofuranone;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
pH=Ca. 2;
Inert atmosphere;
DOI:10.1016/j.tet.2009.11.024
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 24 h / Reflux
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 5.25 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; potassium tert-butylate;
In
tetrahydrofuran; water;
2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1002/hlca.201500267
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / dichloromethane / 12 h
2.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2.33 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / water / 24 h / Reflux
4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
4.2: 5.25 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; sec.-butyllithium;
In
tetrahydrofuran; dichloromethane; water;
4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1002/hlca.201500267
