2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

Base Information

Chemical Name:2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid
CAS No.:1438280-88-6
Molecular Formula:C₂₀H₁₇N₃O₃S
Molecular Weight:379.439
Hs Code.:

Synonyms:2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

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Chemical Property of 2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

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Technology Process of 2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

There total 5 articles about 2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1438280-84-2
3-phenethyl-2-thioxo-2,3-dihydro-1H-pyrimido[5,4-b]indol-4(5H)-one

: 79-11-8
chloroacetic acid

: 1438280-88-6
2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 6h; Reflux;
DOI:10.1021/jm301694x

Reference yield:

: 1885-29-6
anthranilic acid nitrile

: 1438280-88-6
2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / ethanol / 42 h / Reflux

2: potassium tert-butylate / tetrahydrofuran / 2.75 h / 30 °C / Inert atmosphere

3: ethanol / 6 h / Reflux

4: polyphosphoric acid / ethanol / 3.5 h / 110 °C

5: potassium hydroxide / ethanol / 6 h / Reflux

With potassium tert-butylate; sodium hydrogencarbonate; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm301694x

Reference yield:

: 87223-76-5
(2-cyanophenylamino)acetic acid ethyl ester

: 1438280-88-6
2-((4-oxo-3-phenethyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 2.75 h / 30 °C / Inert atmosphere

2: ethanol / 6 h / Reflux

3: polyphosphoric acid / ethanol / 3.5 h / 110 °C

4: potassium hydroxide / ethanol / 6 h / Reflux

With potassium tert-butylate; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm301694x