87223-76-5

Usage

Uses

Used in Pharmaceutical Synthesis:
ETHYL 2-(2-CYANOANILINO)ACETATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex drug molecules.
Used in Organic Chemistry:
In the realm of organic chemistry, ETHYL 2-(2-CYANOANILINO)ACETATE serves as a versatile intermediate for the production of a range of organic compounds, leveraging its functional groups for diverse chemical reactions.
Used in Medicinal Chemistry Research:
ETHYL 2-(2-CYANOANILINO)ACETATE is utilized as a research compound in medicinal chemistry, where its properties are explored for potential applications in drug development, particularly in the area of inhibiting disease processes.
Used in Drug Development:
In drug development, ETHYL 2-(2-CYANOANILINO)ACETATE is used as a precursor in the creation of new drug candidates, especially those targeting cancer treatment, due to its potential inhibitory effects on disease progression.
Used in Cancer Treatment Research:
ETHYL 2-(2-CYANOANILINO)ACETATE is employed as a compound of interest in cancer treatment research, where its capacity to act as an inhibitor is investigated for therapeutic benefits in oncology.

InChI:InChI=1/C11H12N2O2/c1-2-15-11(14)8-13-10-6-4-3-5-9(10)7-12/h3-6,13H,2,8H2,1H3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 28144-70-9 anthranilic acid amide 
• 1885-29-6 anthranilic acid nitrile 

Downstream Products

• 87223-77-6 ethyl 3-amino-1H-indole-2-carboxylate 
• 107127-28-6 3-phenyl-2-thioxo-2,3-dihydro-1H-pyrimido[5,4-b]indol-4(5H)-one 
• 1171632-04-4 ethyl 3-(3-phenethylthioureido)-1H-indole-2-carboxylate 
• 1438280-80-8 2-((5-(2-amino-2-oxoethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)-N-cyclohexylacetamide 
• 1438280-79-5 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)-N-cyclohexylacetamide 
• 1438280-78-4 N-cyclohexyl-2-((5-dodecyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide 
• 1438280-77-3 N-cyclohexyl-2-((4-oxo-5-pentyl-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide 
• 1438280-76-2 N-cyclohexyl-2-((4-oxo-3-phenyl-5-propyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide 
• 1438280-97-7 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid 
• 1438280-96-6 2-((5-dodecyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid 
• 500195-90-4 ethyl 3-(3-cyclohexylthioureido)-1H-indole-2-carboxylate 
• 1438280-95-5 2-((4-oxo-5-pentyl-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid 
• 1438280-94-4 2-((4-oxo-3-phenyl-5-propyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetic acid 
• 1438280-93-3 tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization

A new class of inhibitors of tubulin polymerization based on the 2-alkoxycarbonyl-3-(3′,4′,5′-trimethoxyanilino)indole molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle eff

Identification of substituted pyrimido[5,4-b]indoles as selective toll-like receptor 4 ligands

A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NFκB activators. The most potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse cells. Synthetic modifications of the pyrimido[5,4-b]indole scaffold at the carboxamide, N-3, and N-5 positions revealed differential TLR4 dependent production of NFκB and type I interferon associated cytokines, IL-6 and interferon γ-induced protein 10 (IP-10) respectively. Specifically, a subset of compounds bearing phenyl and substituted phenyl carboxamides induced lower IL-6 release while maintaining higher IP-10 production, skewing toward the type I interferon pathway. Substitution at N-5 with short alkyl substituents reduced the cytotoxicity of the leading hit compound. Computational studies supported that active compounds appeared to bind primarily to MD-2 in the TLR4/MD-2 complex. These small molecules, which stimulate innate immune cells with minimal toxicity, could potentially be used as adjuvants or immune modulators.

Interleukin-4 gene expression inhibitors

This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R1, R2 and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

CERTAIN ARYL FUSED PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and X represents hydrogen, halogen, or hydroxy; W represents an aryl group unsubstituted or substituted with

Pyridopyrimidoindoles. A New Heterocyclic Ring System

The preparation of the novel pyridopyrimidoindole ring system is described via fusion at 180 deg C of ethyl 3-amino-1H-indole-2-carboxylate 8a and several 6-chloronicotinic acid derivatives.Similar fusion of 8a and thiourea yielded a 2-m