TETRAPROPYLAMMONIUM PERRUTHENATE

Base Information

• Chemical Name: TETRAPROPYLAMMONIUM PERRUTHENATE
• CAS No.: 114615-82-6
• Molecular Formula: C12H28NO4Ru
• Molecular Weight: 351.429
• Hs Code.: 28439000
• Mol file: 114615-82-6.mol

Synonyms:TETRAPROPYLAMMONIUM PERRUTHENATE;TETRA-N-PROPYLAMMONIUM PERRUTHENATE;TETRA-N-PROPYLAMMONIUM PERRUTHENATE (VII);TPAP;Tetrapropylammoniumperruthenate,min.97%TPAP;1-Propanaminium, N,N,N-tripropyl-, (T-4)-tetraoxoruthenate(1-);Tetrapropylammonium Perruthenate (TPAP);Tetra-n-propylammonium perruthenate(VII), 98+%

Chemical Property of TETRAPROPYLAMMONIUM PERRUTHENATE

Chemical Property:

• Melting Point: ~160 °C (dec.)(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 74.27000
• Density: g/cm³
• LogP: 2.96800
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly)
• Water Solubility.: Insoluble in water.

Purity/Quality:

97% ^*data from raw suppliers

Tetrapropylammonium Perruthenate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: O,Xi
• Statements: 5-8-36/37/38
• Safety Statements: 17-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A mild oxidant for the selective transformation of primary alcohols to aldehydes and secondary alcohols to ketones. Tetrapropylammonium Perruthenate is used in sustainable oxidation reactions and has potential for chemical recycling.

Technology Process of TETRAPROPYLAMMONIUM PERRUTHENATE

There total 8 articles about TETRAPROPYLAMMONIUM PERRUTHENATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

rhodium(III) chloride hydrate + tetrapropylammonium hydroxide (4499-86-9) → tetrapropylammonium perruthennate (114615-82-6)

Guidance literature:

rhodium(III) chloride hydrate; With sodium bromate; sodium carbonate; In water; at 30 - 40 ℃; for 5h;

tetrapropylammonium hydroxide; at 30 ℃; for 5h; Temperature;

Reference yield: 99.0%

sodium bromate + ruthenium trichloride hydrate (14898-67-0) + tetrapropylammonium hydroxide → tetrapropylammonium perruthennate (114615-82-6)

Guidance literature:

With sodium carbonate; In water; mixt. of RuCl3 and NaBrO3, Na2CO3 in water stirred until color changed to yellow green, addn. of n-Pr4NOH with stirring, deep green pptn.; extd. with alcohol free CH2Cl2, dried over anhydrous Na2CO3, concd. in vac., recrystd. from CCl4; elem. anal.;

Reference yield: 96.0%

ruthenium tetroxide (20427-56-9) + tetrapropylammonium hydroxide → tetrapropylammonium perruthennate (114615-82-6)

Guidance literature:

With K₂CO₃; stirred at 0°C for 3 h; washed with ice-cold H2O, dried in vac.; elem. anal.;

upstream raw materials:

ruthenium trichloride hydrate

sodium periodate

ruthenium tetroxide

tetrapropylammonium hydroxide

Downstream raw materials:

3-(tert-butyldimethylsilanyloxy)propionaldehyde

4-cyclohexylamino-3-nitrobenzaldehyde

1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one

1-(3-Methoxymethoxy-2-oxo-butyl)-2-oxo-6-m-tolyl-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile

Refernces

Synthesis of marine sesterterpenoid dysidiolide

10.1016/S0040-4039(99)02175-9

The research focuses on the stereocontrolled total synthesis of (±)-dysidiolide, a marine sesterterpenoid isolated from the Caribbean sponge Dysidia etheria de Laubenfels. Dysidiolide has been shown to inhibit protein phosphatase cdc25A and the growth of certain cancer cell lines. The synthesis involves an intramolecular Diels–Alder reaction as the key step. Key chemicals used in the process include cyclohexenone, LDA (lithium diisopropylamide), vinylmagnesium bromide, thiophenol, DIBAL-H (diisobutylaluminum hydride), mCPBA (meta-chloroperoxybenzoic acid), propiolic acid, DCC (dicyclohexylcarbodiimide), DMAP (4-dimethylaminopyridine), TBDMS-Cl (tert-butyldimethylsilyl chloride), imidazole, PON-Cl (bis(dimethylamino)phosphoryl chloride), TPAP (tetrapropylammonium perruthenate), NMO (N-methylmorpholine N-oxide), and various reagents for protection and deprotection steps such as TBDMS (tert-butyldimethylsilyl) and benzyl groups. The synthesis also involves several steps of oxidation, reduction, alkylation, and cross-coupling reactions to achieve the final product.