3-(Cyclohexyloxy)aniline

Base Information

• Chemical Name: 3-(Cyclohexyloxy)aniline
• CAS No.: 109421-10-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.273
• European Community (EC) Number: 834-039-7
• Mol file: 109421-10-5.mol

Synonyms:3-(cyclohexyloxy)aniline;109421-10-5;3-cyclohexyloxyaniline;Benzenamine, 3-(cyclohexyloxy)-;SCHEMBL13369995;AKOS009222280;CS-0257918;EN300-68504;G27750;Z335802294

Chemical Property of 3-(Cyclohexyloxy)aniline

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

3-(Cyclohexyloxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)OC2=CC=CC(=C2)N

Technology Process of 3-(Cyclohexyloxy)aniline

There total 1 articles about 3-(Cyclohexyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(cyclohexyloxy)-3-nitrobenzene (145659-70-7) → 3-(cyclohexyloxy)benzeneamine (109421-10-5)

Guidance literature:

With stannous chloride dihydrate; In ethanol; for 12h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.05.028

Reference yield: 98.0%

2-chloroacetylisocyanate (4461-30-7) + 3-(cyclohexyloxy)benzeneamine (109421-10-5) → C15H19ClN2O3 (1067239-50-2)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2008.06.006

Reference yield: 95.0%

2-chloroethyl isothiocyanate (1943-83-5) + 3-(cyclohexyloxy)benzeneamine (109421-10-5) → 1-(2-chloroethyl)-3-(3-(cyclohexyloxy)phenyl)urea (1043931-99-2)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.05.028

upstream raw materials:

1-(cyclohexyloxy)-3-nitrobenzene

Downstream raw materials:

C₁₅H₁₉ClN₂O₃

1-[3-(cyclohexyloxy)phenyl]-3-ethylurea

1-(2-chloroethyl)-3-(3-(cyclohexyloxy)phenyl)urea